Affliction

Af·flic·tion

Affliction

n.
  1. The cause of continued pain of body or mind, as sickness, losses, etc.; an instance of grievous distress; a pain or grief.
    To repay that money will be a biting affliction.
  2. The state of being afflicted; a state of pain, distress, or grief.
    Some virtues are seen only in affliction.