Entry 1 sense Webster, 1913 Monopolistic /(mō̇*nŏp`ō̇*lĭs"tĭk)/ · Mo·nop·o·lis·tic · IPA /məˌnɒpəˈlɪstɪk/ 01 a. Of or pertaining to a monopolist. 1. Of or pertaining to a monopolist.